prevalence of hla-b27 in the group of patients referred to danesh clinical laboratory

background: hla b27 is a sub class of human leukocyte antigen (hla) class i molecule. it was known as the first genetic risk factor associating with ankylosing spondylitis (as). allele frequency of hla-b27 alleles is different across populations. the present study is aimed to investigate the prevalence of hla-b27 in patients referred to danesh clinical laboratory during 2014 to 2015. methods and material: among 178 patient referred to our lab, 171 data were valid. 5ml blood samples were obtained in heparinized tubes for hla typing test. direct typing of the hla-b27 allele was performed by the standard micro lymphocytotoxity test (mlct method). result: a total of 171 patients have been typed for hla-b27. the prevalence of hla-b27 positive was found as 16.4%. conclusion: a national level of hla b27 prevalence approximation is required for public health management particularly because of recent improvements in diagnostic testing for the disorder